What is one contributing factor to a sickle cell episode?

High altitude is a contributing factor to a sickle cell episode because it leads to lower oxygen levels in the environment. Individuals with sickle cell disease already have hemoglobin that can sickle or become rigid under certain conditions, and low oxygen levels exacerbate this tendency. When at high altitudes, the body's oxygen saturation decreases, promoting hemoglobin polymerization, which can result in the sickling of red blood cells. This sickling can lead to vaso-occlusive events, causing pain and potentially severe complications associated with sickle cell disease.

In contrast, low altitude generally ensures better oxygen availability and may not precipitate a sickle cell crisis. Deep relaxation or proper hydration is beneficial for individuals with sickle cell disease as they can help maintain an optimal environment for blood flow and cellular health.