What precaution should be taken during chemotherapy administration?

During chemotherapy administration, it is essential to recognize that chemotherapeutic agents are hazardous substances that pose health risks to both healthcare providers and patients. Therefore, the proper handling of these drugs requires strict adherence to safety protocols.

The correct choice indicates that chemotherapeutic agents necessitate sterile handling due to their potential toxicity and the risk of contamination. This practice helps to protect healthcare workers from exposure to hazardous materials, which can lead to harmful side effects like skin irritation or more serious health concerns over time. Sterile handling includes using appropriate gloves, and other protective gear, and ensuring that all equipment and surfaces are sanitized to minimize exposure risks.

In comparison, using specific syringe sizes for flushing does not address the broader health risks associated with chemotherapy administration. Furthermore, wearing gloves only during administration does not reflect the comprehensive safety measures needed throughout the entire process of handling and preparing these drugs. Finally, advising patients to avoid oral hydration contradicts established protocols for maintaining patient hydration, which can be crucial during treatment. Thus, the necessity for sterile handling of chemotherapy agents is the most critical precaution to ensure the safety of both the patient and the healthcare staff involved in treatment.