Which of the following is a result of folic acid deficiency?

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Folic acid is essential for DNA synthesis and cellular division, particularly in the production of red blood cells (RBCs). A deficiency in folic acid leads to impaired DNA synthesis, which can hinder the maturation of red blood cells in the bone marrow. This results in decreased overall production of RBCs, leading to conditions such as megaloblastic anemia, characterized by the presence of large, immature, and dysfunctional red blood cells.

In cases of folic acid deficiency, the bone marrow cannot produce an adequate number of healthy RBCs to meet the body’s needs. The diminished production directly ties to the lack of folate, which is crucial for the formation of DNA and ultimately influences the rate and effectiveness of RBC creation. Therefore, the correct answer reflects the physiological consequences of not having enough folic acid available for the processes critical to red blood cell formation and function.

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